Celiac & Blood Pressure

[aklap]

After having been on BP meds for 20+ years...I have been doing a trial w/o them. With the Doctor's approval of course!! So far I've been doing pretty good, "professional" readings are 120's/80's. Home readings 130's/80's or lower.

I've found some research...

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12037696

Reversible hypertension following coeliac disease treatment: the role of moderate hyperhomocysteinaemia and vascular endothelial dysfunction.

Aliment Pharmacol Ther. 2004 Jul 1;20(1):73-9.

Lim PO, Tzemos N, Farquharson CA, Anderson JE, Deegan P, MacWalter RS, Struthers AD, MacDonald TM.

Hypertension Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK. limpo@cf.ac.uk

The vascular endothelium maintains a relatively vasodilated state via the release of nitric oxide (NO), a process that could be disrupted by hyperhomocysteinaemia. Since endothelial dysfunction is associated with increased systemic vascular resistance that is the hallmark of sustained arterial hypertension, we hypothesised that in patients with both hypertension and coeliac disease with hyperhomocysteinaemia (via malabsorption of essential cofactors), treatment of the latter disease could improve blood pressure (BP) control. A single patient with proven sustained hypertension and newly-diagnosed coeliac disease had baseline and post-treatment BP and endothelial function assessed by ambulatory BP monitoring (ABPM) and brachial artery forearm occlusion plethysmography respectively. This 49 year-old woman had uncomplicated sustained hypertension proven on repeated ABPM carried out 6 weeks apart (daytime mean 151/92 mm Hg and 155/95 mm Hg), and sub-clinical coeliac disease (gluten-sensitive enteropathy). Initial assessments revealed raised homocysteine levels with low normal vitamin B(12) level. It was likely that she had impaired absorption of essential cofactors for normal homocysteine metabolism. She adhered to a gluten-free diet and was give oral iron, folate and B(6) supplementations as well as B(12) injections for 3 months. Her BP had improved by 6 months and normalised by 15 months (daytime ABPM mean 128/80 mm Hg). There was parallel restoration of normal endothelial function with normalisation of her homocysteine levels. These observations suggest that sub-clinical coeliac disease related hyperhomocysteinaemia might cause endothelial dysfunction, potentially giving rise to a reversible form of hypertension. In addition, this case study supports the notion that irrespective of aetiology, endothelial dysfunction may be the precursor of hypertension. This highlights the need to resolve co-existing vascular risk factors in patients with hypertension.

Publication Types:

* Case Reports


PMID: 12037696 [PubMed - indexed for MEDLINE]

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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15225173

Risk of vascular disease in adults with diagnosed coeliac disease: a population-based study.

West J, Logan RF, Card TR, Smith C, Hubbard R.

Division of Epidemiology and Public Health, Medical School, Queen's Medical Centre, University of Nottingham, Nottingham, UK. joe.west@nottingham.ac.uk

BACKGROUND: It has been suggested that vascular disease mortality may be reduced in coeliac disease because of lower levels of blood pressure, cholesterol and body mass. AIM: To examine whether people with coeliac disease are at reduced risk of various vascular diseases. METHODS: We identified 3,790 adults with diagnosed coeliac disease and 17,925 age- and sex-matched controls in the General Practice Research Database. We estimated odds ratios for diagnosed hypertension, hypercholesterolaemia and atrial fibrillation and hazard ratios for myocardial infarction and stroke. RESULTS: Adults with coeliac disease, compared with controls, were less likely to have had a diagnosis of hypertension [11% vs. 15%, odds ratio 0.68 (95% confidence interval: 0.60-0.76)] or hypercholesterolaemia [3.0% vs. 4.8%, odds ration 0.58 (95% confidence interval: 0.47-0.72)] but slightly more likely to have had atrial fibrillation [2.1% vs. 1.7%, odds ratio 1.26 (95% confidence interval: 0.97-1.64)]. The hazard ratio for myocardial infarction was 0.85 (95% confidence interval: 0.63-1.13), while the hazard ratio for stroke was 1.29 (95% confidence interval: 0.98-1.70). CONCLUSIONS: Although rates of myocardial infarction and stroke were not substantially different, adults with coeliac disease do have a lower prevalence of hypertension and hypercholesterolaemia compared with the general population. The effect of a gluten-free diet on cardiovascular risk factors should be determined before any screening programmes for coeliac disease are instituted.

PMID: 15225173 [PubMed - indexed for MEDLINE]




adults with coeliac disease do have a lower prevalence of hypertension and hypercholesterolaemia compared with the general population.
I guess there are some benefits.
_________________
Al

“We cannot all do great things, but we can do small things with great love.” Mother Teresa

[Guest]

I didn't read all of that, but I know from my own research that magensium as well as other nutrients has an effect on hypertension, especially in the black population. There is some research that shows that blacks have a different physiology in this regard.
Perhaps the reason celiac's have these reactions is due to the malabsorption of nutrients.

Julie

[aklap]

Hi Juile,

You are right on the mag. It is supposed to help with the hypertension. I have been taking mag supps for awhile. As well as fish oil (Omega 3,6,9's) - again - helps hypertension.

Interesting about the African-American population. I know they have other race related health problems too - sickle cell anemia is one I believe.
_________________
Al

“We cannot all do great things, but we can do small things with great love.” Mother Teresa

[maria1223]

ever since I've been DX with celiac my blood pressure has been very low like 100/77 than it will go to 120/80. but I also have crohns & a hiatal hernia I'm wondering if that has anything to do with my blood pressure too.