Onset of coeliac disease: a prospective longitudinal study.

[aklap]

I thought this was appropriate in light of the posts about young children and testing.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14632329

Onset of coeliac disease: a prospective longitudinal study.

Pittschieler K, Gentili L, Niederhofer H.

Department of Paediatrics, Regional Hospital, Bozen, Italy. klaus.pittschieler@asbz.it

AIM: To make a prospective assessment of close family members of patients with coeliac disease (CD) by testing their endomysium (EMA) and antigliadin antibodies once a year over a period of 12 y and to investigate whether and when they would develop a positive serology for CD while on a gluten-containing diet. METHODS: Since first-degree relatives of CD patients have a high prevalence of CD, we screened 92 children and adolescents, all first-degree relatives of coeliac patients, for EMA and total IgA antibodies, once a year. RESULTS: Among 11 relatives, at the time of the first screening, 6 already had a positive serology and histology for CD, while 5 became positive only after a period of 2 to 5 y of negative testing. The jejunal mucosa biopsy of these five relatives with retarded positive serology for CD showed a flat mucosa in four of them and a partial villous atrophy in one. They were all HLA DQ2 positive and clinically silent for CD. CONCLUSION: CD can manifest itself after years of negative serological testing.

PMID: 14632329 [PubMed - indexed for MEDLINE]
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Al

“We cannot all do great things, but we can do small things with great love.” Mother Teresa

[mjbonsais]

Mary Jo here!! Have a nice weekend all.
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I Am Someone Special