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aklap
Joined: 02 Oct 2004
Posts: 8607
Location: WI, USA
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 Posted: Mon Jan 01, 2007 10:32 pm Post subject: The prevalence of coeliac disease in infertility (Nov 1999) |
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The prevalence of coeliac disease in infertility (Nov 1999)
http://humrep.oxfordjournals.org/cgi/content/full/14/11/2759
| Quote: | | An increased incidence of reproductive problems, including infertility, miscarriage, low birth weight newborns, and shorter duration of breast-feeding, are known to exist in women with coeliac disease; some of these conditions are improved by a gluten-free diet. We have tried to ascertain the prevalence of coeliac disease in 99 couples who were being evaluated for infertility, compared with the known prevalence of silent disease in the population of Northern Sardinia, in which it is endemic. Of all women, four tested positive for at least two out of three markers: immunoglobulin A (IgA) antigliadin, immunoglobulin (IgG) antigliadin, and anti-endomysium antibodies, and underwent a jejunal biopsy; three had histological evidence of coeliac disease. One male partner was positive for two markers, and had a diagnostic jejunal biopsy. The prevalence of coeliac disease in infertile women seems higher (three out of 99, 3.03%) in the study group than in the general population (17 out of 1607, 1.06%), and particularly in the subgroup with unexplained infertility (two out of 25, 8%, P < 0.03). Screening for coeliac disease should be part of the diagnostic work-up of infertile women, particularly when no apparent cause can be ascertained after standard evaluation. |
| Quote: | In conclusion coeliac disease, both in the silent and latent form, must be considered and actively ruled out in patients with unexplained infertility. The positive effect of a gluten-free diet should not be neglected, even though the main mechanism responsible for the reduced fertility in women with coeliac disease is still unknown.
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Al
“We cannot all do great things, but we can do small things with great love.” Mother Teresa |
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