Refractory Sprue Info

[aklap]

I'm just colllecting RS info as I find it...

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10931221&dopt=Abstract

Histopathology. 2000 Jul;37(1):70-7. Related Articles, Links

Distinction between coeliac disease and refractory sprue: a simple immunohistochemical method.

Patey-Mariaud De Serre N, Cellier C, Jabri B, Delabesse E, Verkarre V, Roche B, Lavergne A, Briere J, Mauvieux L, Leborgne M, Barbier JP, Modigliani R, Matuchansky C, MacIntyre E, Cerf-Bensussan N, Brousse N.

Department of Pathology and Universite Rene Descartes-Paris V (EA 219), INSERM E 9925, Paris, France.

AIMS: We recently showed that refractory sprue is distinct from coeliac disease, the former being characterized by abnormal intraepithelial T-lymphocytes expressing a cytoplasmic CD3 chain (CD3c), lacking CD3 and CD8 surface expression, and showing TCRgamma gene rearrangements. To take advantage of the abnormal phenotype of CD3c + CD8 - intraepithelial lymphocytes (IEL) in refractory sprue we developed a simple method to distinguish coeliac disease from refractory sprue. METHODS AND RESULTS: Comparative immunohistochemical studies using anti-CD3 and anti-CD8 antibodies were applied on paraffin-embedded and frozen biopsy specimens in refractory sprue (n = 6), coeliac disease (n = 10), healthy controls (n = 5) and suspected refractory sprue (n = 6). Comparable results were obtained on fixed and frozen biopsy specimens. In four of the six patients with suspected refractory sprue, abnormal CD3c + CD8 - IEL and TCRgamma gene rearrangements were found, as in refractory sprue; the remaining two patients had normal (CD3 + CD8 +) IEL and no TCRgamma gene rearrangements. Both patients had coeliac disease, as one failed to comply with a gluten-free diet, while the other was a slow responder. CONCLUSION: This simplified immunostaining method using anti-CD3 and anti-CD8 antibodies on paraffin sections can distinguish active coeliac disease from refractory sprue and should prove useful in clinical practice.

PMID: 10931221 [PubMed - indexed for MEDLINE]

Refractory Sprue by Michelle Melin-Rogovin, University of Chicago Celiac Disease Program

http://www.celiac.com/st_prod.html?p_prodid=877&sid=2KAJFV1FE2kL5xg-00105103187.70

Refractory coeliac sprue is a diffuse gastrointestinal disease - 30 July 2002

http://gut.bmjjournals.com/cgi/content/full/52/2/205



http://www.maladiecoeliaque.com/infpub2.htm




Celiac Presentations at the National Digestive Disease Conference: May 19-22, 2002 - Summary by Laura Yick

http://www.celiac.com/st_prod.html?p_prodid=683

"Dr. Kelly, who is a refractory sprue specialist, had interesting insights into Celiac Disease."
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Al

“We cannot all do great things, but we can do small things with great love.” Mother Teresa

[Padams]

Thank you so much, Al.

It really is such a complicated thing!

Again, Al, from the most lower region of my heart, thank you.

Take care.

-Patrick
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Patrick
06/14/05
I love Danna Korn

[aklap]

bump
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Al

“We cannot all do great things, but we can do small things with great love.” Mother Teresa

[aklap]

bump for HarmonyRow
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Al

“We cannot all do great things, but we can do small things with great love.” Mother Teresa

[aklap]

bump for Lynne
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Al

“We cannot all do great things, but we can do small things with great love.” Mother Teresa