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borst
Joined: 01 Nov 2007
Posts: 2
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 Posted: Mon Nov 05, 2007 10:13 am Post subject: Interpreting celiac panel results |
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Hi, new member here.
I've been trying to tackle my health issues for about 4 years now with no definitive answer. This is my history that i typed up for my new physician that i'm seeing (trying to seek a second opinion). I tried to make it as concise as possible but i have a complicated history.
| Quote: | 2001
- Went to family doctor in with symptom of bright red blood on tissue.
- Had Upper GI series done
- Diagnosed with duodenal ulcer (even though there were no other visible symptoms)
- Underwent HP-PAC treatment
- Blood on tissue intermittantly after, did not think much of it
December 2004
- Came down with sinus infection
- Went to walk-in clinic, prescribed a week long dosage of antibiotics, ibuprofen and anti-inflammatory nasal spray
- During treatment, began having waking morning bowel urgency and loose stool. (this morning urgency has occurred daily without relief for 3 years)
- Blood on tissue became more frequent
- Saw doctor who performed digital exam and then referred to GI specialist to investigate the rectal bleeding.
- Before appointment with GI specialist, saw family doctor who decided to do another upper GI series. Also had liver function test, CBC, abdominal x-ray as well as Gastrin test. All came back normal.
- Found Gastric ulcer through Upper GI test, and put on HP-Pac again
- During treatment, had severe episode of diarrhea, lasting 2 days, could not keep any food down.
- Went to emergency room, given fecal collection kit to test for parasites.
- April 2005, had unexplained weight loss of at least 15 lbs.
- GI specialist in May 2005, underwent sigmoidoscopy, looked normal. Doctor suggested bleeding likely due to fissure. Did not address other gastro. concerns. Seemed dismissive
- Went back to family doctor who decided to order Lower GI series; result: colon was imaged well, and looked normal.
- Doctor began to suspect anxiety as probably cause.
April 2007
- Had a week long episode of stomach flu like symptoms, starting with slight fever, chills, and then week of diarrhea. Unable to eat much of anything.
- Mid April, during exams, started feeling off-balance when standing, slight lightheadedness. Has been constant with no pattern since then. Doctor ordered CBC, came back normal.
- During summer, had another episode of unexplained weight loss of more than 15lbs. Doctor ordered thyroid function test which came back normal. Again, attributed symptoms to likely anxiety issues.
Current symptoms/concerns:
- Continued daily episodes of morning bowel urgency, usually loose stools. Occasionally, there is first a semi-normal stool, followed minutes later by much looser/watery stools. Less frequently, there is visible large amounts of mucus. As well, colour and form of stool at times abnormal; sometimes very light, sometimes contains parts that are almost black. As well, appearance of undigested food present sometimes. Blood on toilet paper as well as streaked on stool frequent.
- Through out rest of day, there is instances of mild discomfort in abdomen, and under right ribcage.
- Constant feeling of off-balance when standing, sometimes severe, sometimes slight.
- Frequent episodes of sore radiating foot pain at night in bed, about 3-4 nights a week.
- Still unsure of reasons for episodes of unexplained weight loss. |
Anyway, the first thing my new physician wanted to do was run some general bloodwork as well as a celiac panel. I got the results back today:
| Quote: | Celiac Panel
- Gliadin IgA ABS = 26 (ref range: <20 KEU/L)
- Gliadin IgG ABS = 20 (ref range: <20 KEU/L)
- Transglutaminase IgA = 17
(under reference range it says <20 = negative, 20-25 = borderline, >25 = positive) |
So my Glidin IgA is positive, my Gliadin IgG borderline, and my Transglutaminase IgA looks negative.
My doctor said I may have a gluten sensitivity but not "full blown Celiac". What do you guys think?
The rest of my bloodwork showed some spikes as well..
| Quote: | - Magnesium = 1.08 (ref range: 0.65-1.05mmol/L)
- Sodium = 146 (ref range: 135-145)
- Potassium = 5.2 (ref range: 5.2)
- Hemoglobin = 174 (ref range: 135-170g/L)
- Hematocrit = 0.51 (ref range: 0.38-0.49 l/l)
- RBC = 5.82 (ref range: 4.2-5.70) |
The bloodwork also included a random glucose test, calcium, vitamin b12, Ferriton, sTSH, T4 Free, Free T3, GGT, AST, Alkaline Phosphatase, all came back within normal range.
I'm getting a referral back to the same gastroenterologist that i had before, hopefully will get some more answers this time
Any advice/suggestions/insight would be appreciated.
Thanks |
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aklap
Joined: 02 Oct 2004
Posts: 8096
Location: WI, USA
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| Posted: Mon Nov 05, 2007 10:23 am Post subject: |
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Hi Borst,
Welcome to the board! Very nicely laid out!! I hope the doc will appreciate it and use it to help you [my gastro toss aside my food journal..].
Didn't get a chance to fully read it all...but there's something going on. You Gliadin levels are off - that's a clue right there. Good for the doc that ran them!! [They are out of favor now, sadly].
Your doc maybe right about the Non Celiac Gluten Sensitivity - based on the Gliadin IgG & IgA tests. However other things can skew those results too.
You could be on the right track!! Definitely worth pursuing!!
I'll be back later, but in the mean time - take a look thru here:
Our Path's to Gluten Free-dom Thread - Stories on how & why we are GF.
I noticed your off balance symptoms - I had that too! If I were driving and stop at a stop sign - it's feel like I was still moving. My balance just wasn't right. ENT doc almost laughed in my face at my CD/Gluten connection [jerk].
Keep going on your Knowledge Quest!!
_________________
Al
“We cannot all do great things, but we can do small things with great love.” Mother Teresa
Last edited by aklap on Mon Nov 05, 2007 10:39 am; edited 1 time in total |
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borst
Joined: 01 Nov 2007
Posts: 2
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| Posted: Mon Nov 05, 2007 10:25 am Post subject: |
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| aklap wrote: | Hi Borst,
Welcome to the board! Very nicely laid out!! I hope the doc will appreciate it and use it to help you [my gastro toss aside my food journal..].
Didn't get a chance to fully read it all...but there's something going on. You Gliadin levels are off - that's a clue right there. Good for the doc that ran them!! [They are out of favor now, sadly].
Your 2nd doc maybe right about the Non Celiac Gluten Sensitivity - based on the Gliadin IgG & IgA tests. However other things can skew those results too.
You could be on the right track!! Definitely worth pursuing!!
I'll be back later, but in the mean time - take a look thru here:
Our Path's to Gluten Free-dom Thread - Stories on how & why we are GF.
I noticed your off balance symptoms - I had that too! If I were driving and stop at a stop sign - it's feel like I was still moving. My balance just wasn't right. ENT doc almost laughed in my face at my CD/Gluten connection [jerk].
Keep going on your Knowledge Quest!! |
Yeah it was these "other things" that have me worried since my TtG was negative (although close to the borderline range)
what other things could skew a gliadin result? |
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aklap
Joined: 02 Oct 2004
Posts: 8096
Location: WI, USA
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| Posted: Mon Nov 05, 2007 10:25 am Post subject: |
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Antibiotics can cause gastro symptoms like you experienced...
Ok - gotta stop reading and get back to work 
_________________
Al
“We cannot all do great things, but we can do small things with great love.” Mother Teresa |
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aklap
Joined: 02 Oct 2004
Posts: 8096
Location: WI, USA
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| Posted: Mon Nov 05, 2007 10:26 am Post subject: |
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Some things are explained here:
Our Thread on Celiac Blood Work Tests - Lists the complete CD blood work panel and links to other testing info.
tTG test are great at picking up large damage - total villous atrophy [villi are completely gone - toast]. But not so good at picking up lesser amounts of damage...
_________________
Al
“We cannot all do great things, but we can do small things with great love.” Mother Teresa |
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