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skyeofblue
Joined: 09 Nov 2007
Posts: 19
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 Posted: Mon Nov 26, 2007 12:31 am Post subject: Normal IgG and IgA and Total IgA, Abnormal TTG and EMA ? |
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Just got my Celiac panel test results back and they are as follows:
Anti-Gliadin IgG ELISA (AGA IgG) 6.8 U/ml
(reference <10.0 U/ml)
Anti-Gliadin IgA ELISA (AGA IgA) 1.2 U/ml
(reference <5.0 U/ml
Anti- Human Tissue Transglutaminase IgA ELISA (TTG IgA) 18.4 U/ml
(reference <4.0 U/ml)
Anti-Endomysial IgA IFA (EMA IgA) Positive
(reference - negative)
Total Serum IgA by Nephelomtry (Total IgA) 165 mg/dl
(reference 44-441 mg/dl)
My doctor said that I had Celiac disease, but my question is if my IgA and IgG and Total IgA levels are normal but I tested positive for celiac disease...what does that mean?
My doctor said that the IgA and IgG testing are not very sensitive tests...and that the Total IgA and TTG and EMA are what they use to diagnose Celiac disease.
But how can I test negative for gluten sensitivity and positive for Celiac disease...or by default because I have Celiac disease does that in turn mean I am gluten intolerant?
Sorry I found out the day before thanksgiving, and my doctor could only briefly go over the results...I am new at this and any new advice on interpreting these results would be helpful!
Thanks  |
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cruelshoes
Joined: 23 Sep 2005
Posts: 2514
Location: Washington State
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| Posted: Mon Nov 26, 2007 9:12 am Post subject: |
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Here is an explanation of the different types of antibodies:
The five major types of antibodies are:
| Quote: | IgA. IgA antibodies are found in areas of the body such the nose, breathing passages, digestive tract, ears, eyes, and vagina. IgA antibodies protect body surfaces that are exposed to outside foreign substances. This type of antibody is also found in saliva and tears. About 10% to 15% of the antibodies present in the body are IgA antibodies. A small number of people do not make IgA antibodies.
IgG. IgG antibodies are found in all body fluids. They are the smallest but most common antibody (75% to 80%) of all the antibodies in the body. IgG antibodies are very important in fighting bacterial and viral infections. IgG antibodies are the only type of antibody that can cross the placenta in a pregnant woman to help protect her baby (fetus).
IgM. IgM antibodies are the largest antibody. They are found in blood and lymph fluid and are the first type of antibody made in response to an infection. They also cause other immune system cells to destroy foreign substances. IgM antibodies are about 5% to 10% of all the antibodies in the body.
IgE. IgE antibodies are found in the lungs, skin, and mucous membranes. They cause the body to react against foreign substances such as pollen, fungus spores, and animal dander. They may occur in allergic reactions to milk, some medicines, and some poisons. IgE antibody levels are often high in people with allergies.
IgD. IgD antibodies are found in small amounts in the tissues that line the belly or chest. How they work is not clear. |
The bloodwork results you got are highly indicative of celiac disease. The short answer as to why your total IgA is normal but your TTG is high is that there is more than one kind of IgA that makes up the total number. You see how more than one of your test results says it is an IgA result? That's because they are testing for specific types of IgA that are indicative of CD. If your IgA on the celiac markers is high and your total IgA is normal, it would stand to reason that you are on the lower end of your other types of IgA (which they did not test you for). The reason they test your total IgA is to see if you are IgA deficient. If you were, they would have to rely on your IgG results.
| Quote: | | But how can I test negative for gluten sensitivity and positive for Celiac disease...or by default because I have Celiac disease does that in turn mean I am gluten intolerant? |
If you tested positive for celiac disease, you are gluten intollerant. Not all people that are gluten intollerant have celiac disease, but all people that have celiac disease are gluten intollerant.
Hope this makes sense. Sorry you got a positive result, but now you have the opportunity to live a long healthy life. Are you going to go ahead with the biopsy? I would encourage you to do so to get the gold standard diagnosis.
_________________
-Colleen
Dx 8/05 via bloodwork/biopsy
10-YO son Dx 11/05 via bloodwork/biopsy
Daughters (12 and 2) have neg. bloodwork
A woman is like a tea bag-you never know how strong she is until she gets in hot water. - Eleanor Roosevelt |
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skyeofblue
Joined: 09 Nov 2007
Posts: 19
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| Posted: Wed Nov 28, 2007 2:39 pm Post subject: Thanks :) |
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Thank you for this information. This helps tremendously!
I have an endoscopy scheduled for Friday and an appointment with a Nutritionist next Wenesday.
Thanks again this helps alot!  |
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cruelshoes
Joined: 23 Sep 2005
Posts: 2514
Location: Washington State
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| Posted: Wed Nov 28, 2007 3:30 pm Post subject: |
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Good luck on your endoscopy. If you are nervous about it, Jen wrote up a good description over here.
_________________
-Colleen
Dx 8/05 via bloodwork/biopsy
10-YO son Dx 11/05 via bloodwork/biopsy
Daughters (12 and 2) have neg. bloodwork
A woman is like a tea bag-you never know how strong she is until she gets in hot water. - Eleanor Roosevelt |
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