Advances in Celiac Disease - CME

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Advances in Celiac Disease - CME
Release Date: April 27, 2005

Peter D. Howdle Gerry G. Robins, MBBS, MRCP, MD
Curr Opin Gastroenterol 21(2):152-161, 2005. © 2005 Lippincott Williams & Wilkins

Abstract and Introduction

Abstract

Purpose of Review: This article aims to summarize recent critical research in celiac disease.

Recent Findings: The crucial epitopes that confer toxicity to gliadin and related prolamins continue to be defined, as do methods of assessing their toxicity. New approaches to making the gluten-free diet more palatable are being studied.

Summary: The position of proline residues is critical to the toxicity of cereal proteins to patients with celiac disease. Other genetic factors, apart from HLA status, remain elusive. Exciting advances in altering the toxicity of cereal proteins are being made.


"The prevalence of CD will increase as more cases are diagnosed with screening. The genetic and racial factors affecting prevalence and treatment may reduce the adverse effects of CD. Review of the immunopathological and inflammatory bases of CD will enhance disease management."
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Al

“We cannot all do great things, but we can do small things with great love.” Mother Teresa