Celiac disease & Sjogren's

[aklap]

For those with Sjogren's (Thanks Cara for finding this!!)

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10201480

Celiac disease and markers of celiac disease latency in patients with primary Sjogren's syndrome.

Iltanen S, Collin P, Korpela M, Holm K, Partanen J, Polvi A, Maki M.

Institute of Medical Technology, University of Tampere, Finland.

OBJECTIVE: Many autoimmune diseases occur concomitantly with celiac disease. We investigated prospectively the occurrence of celiac disease and small-bowel mucosal inflammation in patients with primary Sjogren's syndrome. METHODS: A total of 34 patients with primary Sjogren's syndrome and 28 controls underwent small bowel biopsy. Villous morphology, jejunal intraepithelial lymphocytes, and mucosal HLA-DR were evaluated and DQA and DQB alleles, serum antiendomysial, and antigliadin antibodies were examined. RESULTS: Five (14.7%) of 34 Sjogren's syndrome patients were found to have celiac disease. The density of jejunal intraepithelial gammadelta+ T cells was increased in all celiac and in four nonceliac patients. All celiac patients, 69% of nonceliac Sjogren's syndrome patients, and 11% of control subjects showed enhanced HLA-DR expression (p < 0.001). HLA DQ2 was present in 19 (56%) patients with Sjogren's syndrome, including all five with celiac disease. CONCLUSIONS: The findings show a close association between Sjogren's syndrome and celiac disease. Even among nonceliac patients with primary Sjogren's syndrome, an ongoing inflammation is often present in the small bowel mucosa.

PMID: 10201480 [PubMed - indexed for MEDLINE]
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Al

“We cannot all do great things, but we can do small things with great love.” Mother Teresa