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Increased Risk of Papillary Thyroid Cancer in CD (2006)

 
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aklap



Joined: 02 Oct 2004
Posts: 8602
Location: WI, USA

PostPosted: Fri Sep 08, 2006 8:32 pm    Post subject: Increased Risk of Papillary Thyroid Cancer in CD (2006) Reply with quote

Increased Risk of Papillary Thyroid Cancer in Celiac Disease.


Quote:
1: Dig Dis Sci. 2006 Sep 7; [Epub ahead of print] Links

Kent L,
McBride R,
McConnell R,
Neugut AI,
Bhagat G,
R Green PH.

Department of Medicine, Columbia University College of Physicians and Surgeons, 161 Fort Washington Ave, Room 645, New York, 10032, New York, USA, pg11@columbia.edu.

Patients with celiac disease have an increased rate of malignancies that are not limited to lymphomas. Thyroid carcinoma has not previously been associated with celiac disease. However, among a cohort of patients with celiac disease, we identified an increased risk of papillary carcinoma of the thyroid, standard morbidity ratio of 22.52 (95% confidence interval 14.90-34.04; P < .001), compared to United States national surveillance data. These patients were on a gluten-free diet. Only 1 had Hashimoto's thyroiditis, suggesting that mechanisms apart from autoimmune thyroiditis contribute to the increased risk of carcinoma of the thyroid in celiac disease.
PMID: 16957996 [PubMed - as supplied by publisher]


One more thing to watch out for... Sad
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gluten-free-mike



Joined: 07 Sep 2006
Posts: 349
Location: Cleveland, OH

PostPosted: Wed Sep 13, 2006 12:37 pm    Post subject: Reply with quote

Lovely - never a shortage of related issues it seems.

I have to wonder what the mechanism behind this increased risk is. Since everyone in the study was on a GF diet, and still had increased risk, it seems that the cause must stem from one or more of:

a) damage done to one's body prior to going GF

b) damage from lack of something in a "normal" diet that protects against this condition

c) damage done from an overabundance of something in our GF diets that others would not normally experience

Hopefully they will get a clearer picture of what the root cause is, so we can better plan and avoid the issue (if possible).
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Fidissimus



Joined: 17 Mar 2006
Posts: 1560
Location: Portland, OR.

PostPosted: Wed Sep 13, 2006 6:50 pm    Post subject: Reply with quote

...or perhaps something to do with our malfunctioning autoimmune systems in general. I wish they'd given more info on what they thought was the root cause of the increased risk.
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aklap



Joined: 02 Oct 2004
Posts: 8602
Location: WI, USA

PostPosted: Wed Sep 13, 2006 6:59 pm    Post subject: Reply with quote

It probably will in the full text article - which you probably have to pay to get. This is abstract is out ahead of the article too.
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gluten-free-mike



Joined: 07 Sep 2006
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PostPosted: Wed Sep 13, 2006 7:46 pm    Post subject: Reply with quote

A lot of those scientific papers / journals do that where they only offer abstracts. Now, if you happen to have a friend in academia, many colleges and universities have access to some of those repositories for both their students and faculty. The thing I find most annoying is that there is a good chance that we, the taxpayers, probably funded (in part or in whole) quite a few of the studies whose findings we are later supposed to pay to gain access to.
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annelb



Joined: 05 Aug 2006
Posts: 18
Location: Arkansas

PostPosted: Sun Sep 17, 2006 10:51 am    Post subject: Reply with quote

I think one reason there is increased incidence of other diseases when one has CD is that there is no diagnosis before villous atrophy occurs. How much damage is done to the whole body by that time Question The GF diet does not reverse all damage when there have been years of insult to the body. This article (go to www.pubmed.gov and search for 16810593. For some reason I cannot put the link here.) The article Endoscopic and histological findings in the duodenum of adults with celiac disease before and after changing to a gluten-free diet: a 2-year prospective study. says that people who were diagnosed at age 30 and above had very little healing of the villi after 24 months. If the villi are not healing, I doubt that the rest of the body is healing either.

Another thought - CD is found in about 1% of the population no matter what age group is tested. That seems to indicate that adults have had CD all their life but it was "triggered" by something? IMHO, CD was probably simmering all along until severe symptoms appeared.

The statistic of 1:133 have CD is for asymptomatic people. I wonder if anyone is following those asymptomatic people who refused a GF diet to see if they remain asymptomatic forever. Or will something "trigger" their CD down the line. For people who have symptoms the occurrance is 1:56.

I think Dr. Fine is right when he says diagnosis must occur "Before the Villi are Gone". https://www.enterolab.com/StaticPages/EarlyDiagnosis.htm

I am 63 and have been GF for 3 years. I was diagnosed through enterolab so I don't know what my villi were doing.

Anne
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