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Reproductive aspects of celiac disease (Oct 2005)

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aklap

Joined: 02 Oct 2004
Posts: 8135
Location: WI, USA

Posted: Mon Jan 01, 2007 10:28 pm Post subject: Reproductive aspects of celiac disease (Oct 2005)

Reproductive aspects of celiac disease

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16250182&query_hl=2&itool=pubmed_docsum

Quote:

1: Ann Ital Med Int. 2005 Jul-Sep;20(3):143-57. Links
Erratum in:
Ann Ital Med Int. 2005 Oct-Dec;20(4):263.

[Article in Italian]
Stazi AV,
Trinti B.
Dipartimento Ambiente e connessa Prevenzione Primaria, Reparto di Tossicologia Genetica Istituto Superiore di Sanita, Universita degli Studi La Sapienza, Roma. avelia@iss.it
In the past, celiac disease (CD), or intolerance to gluten, was considered a rare disease of infancy characterized by chronic diarrhea with malabsorption and delayed growth. Besides the overt enteropathy, there are other clinic and subclinical forms which appear later in life. Target organs are not limited to the gut, but include liver, thyroid, skin and female and male reproductive systems. CD interference on reproduction is related to the multifactorial nature of the disease, whose pathological manifestations can be modulated, besides gluten, by different concurrent genetic and environmental factors. CD induces malabsorption with consequent deficiencies of micronutrients such as iron, folic acid and vitamin K, which are essential for organogenesis, and fat-soluble vitamins important for spermatogenesis. Regarding endocrine disorders, the deficiencies of specific trace elements on ovarian function could explain its involvement in the increased risk of female osteoporosis in CD patients. Affected males show a picture of tissue resistance to androgens; the increases of follicle-stimulating hormone and prolactin, not associated with infertility, may indicate an imbalance at hypothalamus-pituitary level, with general effects on health. Since reproductive alterations are reversible, adoption of a gluten-free diet supported by early diagnosis is important. Therefore, the detection of early biomarkers, such as deficiencies of vitamins and/or iron and andrological or endocrinological dysfunctions, should trigger timely strategies for prevention and treatment.
PMID: 16250182 [PubMed - indexed for MEDLINE]

_________________
Al

“We cannot all do great things, but we can do small things with great love.” Mother Teresa

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