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aklap
Joined: 02 Oct 2004
Posts: 8096
Location: WI, USA
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 Posted: Sat Mar 31, 2007 10:23 pm Post subject: Screening for Celiac Disease in Family Members |
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Screening for Celiac Disease in Family Members: Is Follow-up Testing Necessary? (2007)
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17380406&query_hl=1&itool=pubmed_DocSum
| Quote: | 1: Dig Dis Sci. 2007 Apr;52(4):1082-6. Epub 2007 Feb 16. Links
Goldberg D,
Kryszak D,
Fasano A,
Green PH.
Department of Medicine, Columbia University College of Physicians and Surgeons, 161 Fort Washington Avenue, New York, New York, 10032, USA, pg11@columbia.edu.
Celiac disease is a genetically determined intolerance to gluten that results in villous atrophy in the small intestine. Because celiac disease occurs in families, relatives of affected individuals are tested for the disease. However, there are no evidence-based guidelines for when, or how often, to test relatives. Our goal was to determine if one-time screening of relatives is sufficient. Of 171 family members with an initially negative endomysial antibody who were tested on more than one occasion, 6 (3.5%) were positive on repeat testing. The average time to seroconversion was 1.7+/-1.2 years (range, 6 months-3 years 2 months). Only one of the seroconverters had diarrhea; the remainder were asymptomatic. None of the patients had a change in symptoms between testing.
We conclude that one-time testing for celiac disease among families with affected members is insufficient. Repeat testing should occur irrespective of the presence of symptoms.
PMID: 17380406 [PubMed - in process] |
Very interesting study...
Those of you with non celiac family members - keep on testing them - regardless of symptoms! Average length of time to seroconversion is 1.7 years for 3.5% that converted.
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Al
“We cannot all do great things, but we can do small things with great love.” Mother Teresa |
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isto
Joined: 30 Sep 2005
Posts: 1083
Location: OHIO
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| Posted: Sun Apr 01, 2007 8:24 am Post subject: |
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Thanks, Al!
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